The Brand Name PURINETHOL Has Generic Salt :: Mercaptopurine 

PURINETHOL  Is From Company Gsk Priced :: Rs. 201.18

PURINETHOL have Mercaptopurine is comes under Sub class Drugs for Inflammatory Bowel Disease of  Main Class Gastrointestinal System

Main Medicine Class:: Gastrointestinal System  Sub Medicine Class :: Drugs for Inflammatory Bowel Disease 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Mercaptopurine  TAB  Rs. 201.18  25
Brand Name Company / Manufacturers Strength Unit Price / 25
 PURINETHOL  Gsk  50MG  25 Rs. 201.18

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Gsk :: PURINETHOL  Mercaptopurine  Gastrointestinal System Drugs for Inflammatory Bowel Disease

Indications for Drugs ::

Acute lymphatic leukaemia, Crohn’s disease

Drug Dose ::

Oral Acute lymphatic leukaemia Adult: Usual maintenance dose: Initially, 1.5-2.5 mg/kg daily as a single dose, usually used in combination with methotrexate. Dose may vary individually based on response and tolerance. Monitor blood counts at least once wkly. Withdraw treatment immedietely if there is a sharp drop in the white cell count or severe bone-marrow depression. May resume treatment slowly and carefully if white cell count remains constant for 2-3 days or rises. Reduce dose when used with allopurinol. Child: Usual maintenance dose: Initially, 1.5-2.5 mg/kg daily as a single dose, usually used in combination with methotrexate. Dose may vary individually based on response and tolerance. Monitor blood counts at least once wkly. Withdraw treatment immedietely if there is a sharp drop in the white cell count or severe bone-marrow depression. May resume treatment slowly and carefully if white cell count remains constant for 2-3 days or rises. Reduce dose when used with allopurinol. Hepatic impairment: Dosage may need to be reduced Crohn’s disease Adult: Initially 1-1.5 mg/kg daily, may increase to 125 mg daily. Child: Initially 1-1.5 mg/kg daily increased to a max of 75 mg daily Hepatic impairment: Dosage may need to be reduced.

Contraindication ::

Pregnancy and lactation. Prior resistance to mercaptopurine or thioguanine; severe liver disease; severe bone marrow suppression.

Drug Precautions ::

Hepatic or renal dysfunction; monitor hepatic function periodically. Mercaptopurine is potentially carcinogenic. Thiopurine S-methyl transferase (TPMT) deficiency; porphyria.

Drug Side Effects ::

Hyperuricaemia, bone marrow toxicity, hypoplasia, anorexia, diarrhoea, leukopenia, thrombocytopenia, intestinal ulceration, crystalluria with haematuria, immunosuppression, interstitial pneumonitis. Cutaneous hyperpigmentation, alopecia. Potentially Fatal: Myelosuppression; hepatotoxicity, cholestatic jaundice.

Pregnancy category ::
Pregnancy category

4

Drug Mode of Action ::  

Mercaptopurine is a purine antagonist which is converted intracellularly into its active nucleotides, including thioinosinic acid. The nucleotides inhibit several reactions which ultimately interferes with nucleic acid synthesis and prevents the formation of RNA and DNA.

Drug Interactions ::

Anticoagulant action of warfarin may be inhibited by mercaptopurine. Enhanced toxicity with myelosuppressive drugs. Potentially Fatal: Effects enhanced by allopurinol (reduce dose of mercaptopurine). Other hepatotoxic drugs (e.g. doxorubicin) potentiate toxicity.

 

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

DOWNLOAD OUR ANDROID APP

One of the 1st in India.High Quality Generic Medicine Portal Android Application for Online Oreder & Information.

For More Join Our Membership and Get Additional 25% off on Meds, also get MLM Benefits to get a permanent earning source.

Join Membership How to Search Medicine
Android App

We would like to keep you updated with special notifications.