The Brand Name PYRIDO Has Generic Salt :: Pyridostigmine
PYRIDO Is From Company SG PH. Priced :: Rs. 180
PYRIDO have Pyridostigmine is comes under Sub class Miscellaneous of Main Class Anti Infectives
Main Medicine Class:: Anti Infectives Sub Medicine Class :: Miscellaneous
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Indications for Drugs ::
Reversal of neuromuscular blockade,Myasthenia gravis,Paralytic ileus and post-operative urinary retention
Drug Dose ::
Oral Myasthenia gravis Adult: 0.3-1.2 g daily in divided doses. Child: <6 yr: initially, 30 mg, 6-12 60 mg. dose may be gradually increased by 15-30 mg on a daily basis until satisfactory response is observed. neonatal myasthenia gravis child: 5-10 given every 4-6 hr. paralytic ileus and postoperative urinary retention adult: doses of 60-240 mg. Contraindication ::
GI or urinary obstruction.
Drug Precautions ::
Renal impairment, pregnancy and lactation, epilepsy, bronchial asthma, bradycardia, cardiac arrhythmias, recent coronary occlusion, vagotonia, hyperthyroidism, peptic ulcer, recent bladder/intestinal surgery. Care should be taken in the use of atropine for counteracting side effects.
Drug Side Effects ::
Muscarinic side effects e.g. nausea, vomiting, diarrhoea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis. Nicotinic side effects include muscle cramps, fasciculation and weakness.
Pregnancy category ::
Drug Mode of Action ::
Pyridostigmine bromide is a potent reversible inhibitor of acetylcholinesterase, the enzyme responsible for destroying acetylcholine. Inhibiting the enzyme allows free transmission of nerve impulses across the neuromuscular junction. Pyridostigmine bromide has a carbonyl ester linkage that is hydrolysed by acetylcholinesterase but much more slowly than is acetylcholine itself.
Drug Interactions ::
Excretion blocked by probenecid.