Pyridostigmine

Details About Generic Salt ::  Pyridostigmine 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Miscellaneous

14E. MISCELLANEOUS in 14. IMMUNOLOGY & ALLERGY
PYRIDOSTIGMINE
CHOLINERGIC | ANTI-MYASTHENIC
PK: A: Very poor D: 19±12 L M: Hepatic E: Urine (80-90% as unchanged drug)

Indications & Dose: MYASTHENIA GRAVIS PO Adult Initialiy 60mg TID, MD 60mg-1.5g, max 600mg Child 7mg/kg/day divided in 5-6 doses | NEONATAL MYASTHENIA GRAVIS PO Child 5mg q4-6h | IM Child 0.05-0.15mg/kg q4-6h | POSTOPERATIVE URINARY RETENTION/PARALYTIC ILEUS PO Adult 60-240mg | REVERSE NEUROMUSCULAR BLOCKADE IV Adult 10-20mg with/preceded by atropine (0.6-1.2mg) to counteract any muscarinic effects

Contra: Hypersensitivity, GI/ GU obstruction

Precautions: Asthma, CVD, seizure, hyperthyroidism, children

ADR: Serious: Arrhythmias, AV block, cardiac arrest, hypotension, syncope, ECG changes, convulsions, arthralgia, myalgia, muscle cramps, bronchospasm, anaphylaxis, respiratory arrest, respiratory muscle paralysis, lacrimation, thrombophlebitis, fasciculations, paralysis, Others: dizziness, drowsiness, dysphonia, loss of consciousness, dyspnea, urticaria

DDI: Serious Procainamide/Norfloxacin aggravates myasthenic symptoms, β-blockers causes bradycardia & hypotension, Ranitidine reduces drug renal clearance

Diet:

Monitor: vital signs, ECG, CVS& respiratory status

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