Quinine

Details About Generic Salt ::  Quinine 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

13J. ANTI-MALARIALS in 13. ANTI-INFECTIVES
QUININE
4-METHANOLQUINOLINE DERIVATIVE | ANTI-MALARIAL, SKELETAL MUSCLE RELAXANT
PK: A: Rapid D: 0.9 L/kg (child), 2.5-7.1 L/kg (adults) M: Hepatic E: Urine

Indications & Dose: MALARIA PO Adult As sulfate or hydrochloride or dihydrochloride: 600mg q8h 7 days Child 10mg/kg q8h 7 days | NOCTURNAL LEG CRAMPS PO Adult 200-300mg HS (as sulfate or bisulfate) Child 10mg/kg body weight q8h 7 days | PLASMODIUM FALCIPARUM MALARIA Complicated/Severe IV Adult Loading dose 20mg/day (as dihydrochloride), max 1.4g over 4h with maintenance infusions after 8h (calculated from the start of previous infusion)

Contra: Hypersensitivity, history of hypersensitivity reactions, G6PD deficiency, optic neuritis, tinnitus, nocturnal leg cramps

Precautions: Myasthenia gravis, history of arrhythmia, CVD

ADR: Serious: atrial fibrillation, AV block, cardiac arrest, hypotension, irregular rhythm, QT prolongation, tachycardia, seizure, blood disorders, SJS, TEN, erythema multiforme, hepatitis, pulmonary edema, Others: tinnitus, myalgia, dyspnea, hypoglycemia, GI irritation, nausea, vomiting, dermatitis, cutaneous rash, confusion, dizziness, headache

DDI: Serious Aluminum Hydroxide Gel delays/decreases drug absorption, Rifampicin leads to subtherapeutic drug level, Digoxin toxicity occurs

Diet: With/without food

Monitor: signs & symptoms of hypersensitivity reaction, cinchonism, CBC, LFT

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