The Brand Name R-FLOX Has Generic Salt :: Norfloxacin
R-FLOX Is From Company Reliance Priced :: Rs. 20.04
R-FLOX have Norfloxacin is comes under Sub class Quinolones of Main Class Anti Infectives
Main Medicine Class:: Anti Infectives Sub Medicine Class :: Quinolones
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Indications for Drugs ::
Uncomplicated urinary tract infections (including cystitis), Uncomplicated urethral and cervical gonorrhea, Prostatitis, Gastroenteritis
Drug Dose ::
Adult: PO Uncomplicated gonorrhoea 800 mg once daily. Susceptible infections 400 mg twice daily. Duration: Chronic bacterial prostatitis: 28 days; Complicated UTI: 10-21 days; Gastroenteritis: 3-5 days; Uncomplicated UTI caused by susceptible Escherichia coli, Klebsiella pneumoniae, roteus mirabilis species: 3 days; Uncomplicated UTI caused by other susceptible bacteria: 7-10 days. Chronic relapsing UTI 400 mg twice daily, up to 12 wk, may reduce to once daily if adequate suppression w/in 1st 4 wk. Renal impairment: CrCl (ml/min) <30 400 mg once daily Contraindication ::
Hypersensitivity to quinolones; children <18 yr. lactation. Drug Precautions ::
Renal impairment; history of CNS disorders; myasthaenia gravis. Pregnancy. QT prolongation; discontinue if signs of neuropathy occur.
Drug Side Effects ::
Nausea, vomiting, heartburn, constipation, diarrhoea, abdominal cramping, anorexia; headache, dizziness; depression, insomnia; phototoxicity; rash, fever, arthralgia; elevated liver enzymes, urea and creatinine. Eosinophilia, neutropenia, thrombocytopenia and anaemia; hyperhidris; tendon rupture; QT prolongation. Potentially Fatal: Anaphylaxis, acute renal failure, seizures.
Pregnancy category ::
Drug Mode of Action ::
Norfloxacin inhibits the action of DNA gyrase in DNA replication, transcription, repair, recombination and transposition.
Drug Interactions ::
Additive effect on QT interval prolongation w/ class IA (e.g. quinidine) or class III (e.g. amiodarone) antiarrhythmics and other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents). Increased serum concentrations of theophylline. Reduced absorption w/ oral multivitamins and mineral supplements containing divalent or trivalent cations (e.g. Fe, Zn) and antacids containing Al or Mg, sucralfate, buffered didanosine. Prolonged prothrombin time w/ concomitant coumarin anticoagulant. Increased risk of severe tendon disorders w/ corticosteroids. Concurrent use w/ NSAIDs may increase the risk of CNS stimulation and convulsive seizures.