Raloxifene

Details About Generic Salt ::  Raloxifene 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Drugs affecting Bone Metabolism

8I. DRUGS AFFECTING BONE METABOLISM in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
RALOXIFENE
NON STEROIDAL BENZOTHIOPHENE DERIVATIVE | SELECTIVE ESTROGEN RECEPTOR MODULATOR
PK: A: Rapid D: 2348L/kg M: Hepatic E: Feces & urine

Indications & Dose: INVASIVE BREAST CANCER RISK REDUCTION PO Adult 60mg OD 5 yr in females | OSTEOPOROSIS PO Adult 60mg OD in females

Contra: hypersensitivity, history of/current venous thromboembolic disorders

Precautions: hepatic/renal impairment, CVD, hypertriglyceridamia, prolonged immobilization

ADR: Serious: hot flashes, breast pain, vaginal bleeding, bronchitis, peripheral edema, arthralgia, muscle spasm, flu syndrome, venous thromboembolism, endometrial disorder, myalgia, Others: diaphoresis, insomnia, weight gain, uterine disorder, pneumonia, sinusitis

DDI: Serious Warfarin decreases PT, Levothyroxine increases TSH level & symptoms of hypothyroidism, Colestyramine/Colestipol reduces drug absorption

Diet: Without food

Monitor: BMD, lipid profile, diagnostic measures, endometrial sampling, vaginal bleeding

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