Ramipril

Details About Generic Salt ::  Ramipril 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Anti Hypertensives

4D. ANTI-HYPERTENSIVES in 4. CARDIOVASCULAR SYSTEM
RAMIPRIL
ACEI | ANTI-HYPERTENSIVE
PK: A: Well absorbed M: Hepatic E: Urine (60%) & feces (40%)

Indications & Dose: HYPERTENSION PO Adult Initially 1.25mg OD, MD 2.5-5mg/day as single dose up to 10mg/day as neededFirst dose should be given at bedtime | MAJOR CV EVENTS Prophylactic therapy PO Adult 2.5mg OD 1 wk, then 5mg OD next 3 wk, dose may be increased as tolerated to MD 10mg OD | POST MI PO Adult Initially 2.5mg BID, increased to 5mg BID after 2 days MD 2.5-5 mg BID

Contra: hypersensitivity, angioedema with previous ACEI use

Precautions: cholestatic jaundice, cough, hyperkalemia, hypotension/syncope, hypertrophic cardiomyopathy with obstruction, severe aortic stenosis, surgery, pre-existing renal impairment, concomitant therapy with ARBs

ADR: Serious: hypotension/postural hypotension, syncope, angina, hyperkalemia, renal impairment, increased Secr, Others: nausea, vomiting, cough, rash, urticaria

DDI: Serious Telmisartan increases hypotensive symptoms, syncope, renal impairment & hyperkalemia, Aliskiren leads to marked reduction in BP, Sirolimus results in tongue edema

Diet: With/without food

Monitor: BP, Secr, K levels, CBC

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