Ranolazine

Details About Generic Salt ::  Ranolazine 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Anti Anginals

4C. ANTI-ANGINALS in 4. CARDIOVASCULAR SYSTEM
RANOLAZINE
CARDIOVASCULAR DRUG | ANTI-ANGINAL
PK: A: Highly variable M: Hepatic E: Urine

Indications & Dose: ANGINA Chronic PO Adult 500mg BID max 1g BID Elderly Initiate low dose

Contra: Strong CYP3A inhibitors & inducers, hepatic impairment

Precautions: mild-to-moderate hepatic impairment, elderly, renal impairment, history of malignant neoplasms, history of adenomatous polyps, QT prolongers

ADR: Serious: Orthostatic hypotension, QT prolongation, syncope, bradycardia, peripheral edema, dyspnea, hematuria, paresthesia, tinnitus, Others: dizziness, headache, constipation, vertigo, dry mouth, abdominal pain, vomiting, blurred vision

DDI: Serious Corticosteroids/Amphotericin-B/Laxatives/Loop diuretics/Thiazides causes hypokalemia, HIV protease inhibitors increases drug level leads to QT interval prolongation, Verapamil/Diltiazem increases risk of adverse effects of drug, Ciclosporin/Atorvastatin/Digoxin/Lovastatin/Simvastatin levels increases, Azoles raises drug level, Phenobarbital/Carbamazepine/Phenytoin/Rifabutin/Rifampicin reduces drug level

Diet: With/without food

Monitor: ECG, BP

Related Posts:
You May Also Like::
Tagged with