Rasagiline

Details About Generic Salt ::  Rasagiline 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

1F. DRUGS FOR NEURODEGENERATIVE DISORDERS in 1. NERVOUS SYSTEM
RASAGILINE
MAO TYPE B INHIBITOR | ANTI-PARKINSONIAN
PK: A: Rapid M: Hepatic E: Urine, feces

Indications & Dose: PARKINSON’S DISEASE Mono therapy PO Adult 1mg OD | Combination therapy/Adjunct therapy PO Adult Initially 0.5mg/day, may increase to 1mg/day (based on response and tolerability) with levodopa

Contra: concomitant use of cyclobenzaprine/dextromethorphan/methadone/propoxyphene/tramadol/st.john’s wort, concomitant use of MAOIs/meperidine within 14 days of rasagiline, moderate to severe hepatic impairment

Precautions: mild hepatic impairment

ADR: Serious: leucopenia, arthralgia, arthritis, depression, conjunctivitis, cerebrovascular accidents, MI, orthostatic hypotension, angina pectoris, Others: dyspepsia, anorexia, hallucinations, skin rashes, melanoma, urinary urgency, vertigo, rhinitis, Headache, flu-like syndrome, malaise, neck pain

DDI: Serious Entacapone increases rasagiline clearance by 28%, Ciprofloxacin increases rasagiline levels, Trazodone lead to adverse effects (serotonin syndrome) Others MAOIs causes hypertensive reactions, SSRIs causes serotonin syndrome and other serious CNS disturbances

Diet: Without food

Monitor: BP, symptoms of parkinsonism, general mood & behavior, skin examination for presence of melanoma

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