Repaglinide

Details About Generic Salt ::  Repaglinide 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
REPAGLINIDE
MEGLITINIDE DERIVATIVE | ANTI-DIABETIC
PK: A: Rapid D: 31 L (Vd) M: Hepatic E: Feces (90%) & urine (8%)

Indications & Dose: TYPE 2 DIABETES MELLITUS PO Adult Initially 500µg, adjust dose according to response at an intervals of 1–2 wk, max 4mg as single dose, total of 16mg/day given as mono therapy or in combination with metformin/thiazolidinedione

Contra: Hypersensitivity, DKA, type 1 DM, concurrent gemfibrozil therapy

Precautions: Substitute insulin during intercurrent illness, elderly, hepatic/renal impairment, malnourished patients

ADR: Serious: IHD, hypoglycemia, anaphylactoid reaction, arrhythmia, blurred vision, hemolytic anemia, hepatic dysfunction, HTN, SJS, thrombocytopenia, Others: alopecia, URTI, chest pain, diarrhea, constipation, tooth disorder, UTI, back pain, arthralgia, allergy, Headache

DDI: Serious Trimethoprim/Itraconazole increases drug level Others Fosphenytoin/Carbamazepine/Phenobarbital/Phenytoin/Primidone may reduce drug levels and efficacy, Rifampicin reduces drug effects, Gatifloxacin/Clarithromycin/Gemfibrozil/Telithromycin results in hypoglycemia

Diet: Before food (30 min)

Monitor: Glucose, HbA1c levels, weight & lipid profile

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