The Brand Name REXGARD Has Generic Salt :: Miconazole
REXGARD Is From Company Sandoz Priced :: Rs. 24
REXGARD have Miconazole is comes under Sub class Anti Microbials (Fungal, of Main Class Skin
Main Medicine Class:: Skin Sub Medicine Class :: Anti Microbials (Fungal,
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Indications for Drugs ::
Oropharyngeal candidiasis, Oral thrush, Denture stomatitis, Fungal infections of the mouth, Throat and gut, Angular cheilitis, Dermatomycoses, Tinea pedis, Tinea corporis, Tinea cruris, Tinea versicolor
Drug Dose ::
For oral administration: The usual dose is 15 mg/kg/day in divided doses. Adults : 1-2 tea-spoonfuls of gel 4 times daily. Children aged 6 years and over : 1 tea-spoonful of gel 4 times daily. Children aged 2-6 years : 1 tea-spoonful of gel twice daily1 month – 2 years : 1/2 tea-spoonful of gel twice daily. Localised lesions of mouth:Smear small amount on affected area with clean finger 4 times daily for 5-7 days.
Miconazole Oral Gel is contraindicated in patients with known hypersensitivity to any of its components and in patients with liver dysfunction.
Drug Precautions ::
Caution is required particularly in infants & young children to ensure that the gel does not obstruct the throat.
Drug Side Effects ::
Nausea, vomiting, diarrhoea (with long-term treatment); rarely allergic reactions; isolated reports of hepatitis.
Pregnancy category ::
Drug Mode of Action ::
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.
Drug Interactions ::
May increase anticoagulant effect of warfarin. May increase or prolong the effect of the following drugs: Oral hypoglycaemics (e.g. sulfonylureas), phenytoin, HIV protease inhibitors (e.g. saquinavir), antineoplastic agents (e.g. vinca alkaloids, busulfan, docetaxel), Ca channel blockers (e.g. dihydropyridines, verapamil), immunosuppressive agents (e.g. ciclosporin, tacrolimus, sirolimus), carbamazepine, cilostazol, buspirone, disopyramide, alfentanil, sildenafil, alprazolam, brotizolam, midazolam IV, rifabutin, methylprednisolone, trimetrexate, ebastine and reboxetine. Potentially Fatal: Increased risk of cardiac arrhythmia w/ astemizole, cisapride, dofetilide, halofantrine, mizolastine, pimozide, quinidine, sertindole, terfenadine. May increase exposure to ergot alkaloids leading to ergotism. May increase the risk of rhabdomyolysis w/ HMG-CoA reductase inhibitors (e.g. simvastatin and lovastatin). May increase the effect of triazolam and oral midazolam.