The Brand Name RHOFENID Has Generic Salt :: Ketoprofen
RHOFENID Is From Company Nicholas Priced :: Rs. 40.62
RHOFENID have Ketoprofen is comes under Sub class Analgesics , Anti inflammatory Drugs of Main Class Musculoskeletal Disorders , Pain
Main Medicine Class:: Musculoskeletal Disorders , Pain Sub Medicine Class :: Analgesics , Anti inflammatory Drugs
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Indications for Drugs ::
Rheumatic disorders, Musculoskeletal pain, Pain and inflammation
Drug Dose ::
Adult: As 2.5% gel: Apply onto affected areas 2-4 times daily for up to 10 days. As 30 mg plaster: Apply 1 plaster bid.
For all routes: Hypersensitivity to aspirin or other NSAIDs or those suffering from asthma, angioedema, urticaria or rhinitis. Active GI disease (e.g. bleeding or ulcer). Severe heart failure, and renal insufficiency. Treatment of perioperative pain in the setting CABG surgery. Rectal: Patients w/ history of proctitis or haemorrhoids.
Drug Precautions ::
History of GI disease (e.g. bleeding or ulcer). Hypertensive patients; renal or hepatic impairment. Pregnancy, lactation, elderly. Monitoring Parameters Close monitoring of BP during initiation and throughout the therapy. Complete blood cell count, chemistry profile, liver and renal function test performed periodically for patients receiving long-term ketoprofen therapy.
Drug Side Effects ::
HTN; GI symptoms e.g. dyspepsia, discomfort, nausea, diarrhoea; pain and tissue damage at inj site (IM). Cardiovascular toxicity (chest pain, dyspnea, weakness, slurred speech). May mask the usual signs and symptoms of infection. NSAID-induced liver dysfunction, anaphylactoid reaction (e.g. difficulty breathing, swelling of the face or throat); photosensitivity reactions (topical).
Pregnancy category ::
Drug Mode of Action ::
Ketoprofen exhibits anti-inflammatory, analgesic and antipyretic properties. It potently inhibits the enzyme cyclooxygenase resulting in prostaglandin synthesis inhibition.
Drug Interactions ::
Increases plasma concentrations of lithium and methotrexate. Reduces effects of antihypertensives (e.g. ACE inhibitors, angiotensin II receptor antagonists). Increased risk of GI bleeding w/ warfarin. Decreased protein binding of ketoprofen and increased risk for serious GI events w/ aspirin and other NSAIDs. Increased risk of developing renal failure w/ diuretics. Increased risk of GI bleeding and ulceration w/ corticosteroids. Increased plasma levels w/ probenecid. Salicylate reduces conjugation and renal elimination of ketoprofen.