Risedronic Acid

Details About Generic Salt ::  Risedronic Acid 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

8I. DRUGS AFFECTING BONE METABOLISM in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
RISEDRONIC ACID
BISPHOSPHONATE | CALCIUM REGULATOR
PK: A: Rapid D: 13.8L/kg(Vd) M: None E: Urine & feces

Indications & Dose: OSTEOPOROSIS PO Adult IR tablet: 35mg weekly once in males | OSTEOPOROSIS DRUG INDUCED PO Adult Prevention & treatment: 5mg OD | OSTEOPOROSIS IN POSTMENOPAUSAL PO Adult IR tablet: Prevention & treatment: 5mg OD or 35mg weekly once or 150mg monthly once, Delayed release tablet: 35mg weekly once | PAGET’S DISEASE OF BONE PO Adult 30mg OD 2 month, re-treatment may be considered if relapse occurs or treatment fails to normalize serum alkaline phosphatase

Contra: Hypersensitivity, upper GI inflamation

Precautions: Hepatic/renal impairment, hypotension, difficulty in swallowing, hypocalcemia

ADR: Serious: electrolyte disturbances, HTN, increase PTH levels, arthralgia, arrhythmia, prostatic hyperplasia, nephrolithiasis, bronchitis, myalgia, Others: neck pain, muscle spasm, cataract, nausea, constipation, dyspepsia, flu-like syndrome

DDI: Serious Aminoglycosides causes additive hypocalcemic effects, NSAIDs increases GI/renal adverse effects

Diet: Early morning on empty stomach(with 180ml of water)

Monitor: BMD of hip/spine before therapy, annual measurements of height & weight, assessment of chronic back pain, serum Ca, biochemical markers of bone turnover

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