Rizatriptan

Details About Generic Salt ::  Rizatriptan 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

1H. ANTI-MIGRAINE & ANTI- VERTIGO DRUGS in 1. NERVOUS SYSTEM
RIZATRIPTAN
5-HT1 AGONIST | ANTI-MIGRAINE
PK: M: Hepatic E: Urine (82%); feces (12%)

Indications & Dose: MIGRAINE Acute PO Adult Initially 10mg if symptoms recur, another 10mg after 2h max 20mg/day (5mg in patients on propranolol max 10mg/day)Discontinue if ineffective for the first dose

Contra: Hypersensitivity, IHD/Prinzmetal’s angina, uncontrolled HTN, severe hepatic/renal impairment

Precautions: Mild-to-moderate hepatic/renal impairment

ADR: Serious: TEN, coronary artery vasospasm, transient ischemia, MI, ventricular tachycardia/fibrillation, cardiac arrest, cerebral/subarachnoid hemorrhage, stroke, hypertensive crisis, peripheral vascular ischemia, colonic ischemia

DDI: Serious Propranolol increases drug level, Moclobemide markedly inhibits drug metabolism

Diet: Before food

Monitor: Headache severity, ECG, HR, BP

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