Saxagliptin

Details About Generic Salt ::  Saxagliptin 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
SAXAGLIPTIN
DPP-4 INHIBITOR | ANTI-DIABETIC
PK: A: >75% D: 151 L (Vss) M: Hepatic E: Urine & feces

Indications & Dose: TYPE 2 DIABETES MELLITUS PO Adult 2.5-5mg OD

Precautions: moderate-to-severe renal dysfunction, strong CYP3A4/5 inhibitors, insulin secretagogues

ADR: Serious: peripheral edema, hypoglycemia, sinusitis, idiopathic thrombocytopenic purpura, Others: headache, lymphopenia, abdominal pain, UTI, hypersensitivity, gastroenteritis, vomiting

DDI: Serious Diltiazem/Clarithromycin/Itraconazole/Ketoconazole increases drug level, Thiazolidinedione increases risk of peripheral edema, Dexamethasone/Carbamazepine/Phenobarbital/Phenytoin/Rifampicin reduces drug level

Diet: With/without food

Monitor: Plasma glucose, renal function, Hb

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