Selegiline

Details About Generic Salt ::  Selegiline 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Drugs for Neurodegenerative Disorders

1F. DRUGS FOR NEURODEGENERATIVE DISORDERS in 1. NERVOUS SYSTEM
SELEGILINE
MAOI | ANTI-PARKINSONIAN, ANTI-DEPRESSANT
also comes under 1D. Anti-Depressants in 1. Nervous System
PK: A: Rapid (PO), 25%-30% (TD) M: Hepatic E: Urine & feces

Indications & Dose: DEPRESSION TD Adult Initially 6mg OD, dose may be titrated to 3mg/day q2wk, max 12mg/day if required Elderly 6mg OD | PARKINSON’S DISEASE Mono therapy PO Adult 5mg BID or 10mg OD. For dispersible tablet: Initially 1.25mg/day 6 wk, may increase to 2.5mg/day based on clinical response, max 2.5mg/day Elderly 5mg OD, may be increased to 10mg

Contra: Active ulcer, hypersensitivity, concomitant drug therapy, pheochromocytoma

Precautions: PUD, uncontrolled HTN, arrhythmias, angina, severe liver/ kidney dysfunction, psychosis

ADR: Serious: orthostatic hypotension, myopathy, Others: chest pain, nausea, vomiting, constipation, diarrhea, confusion, headache, tremor, vertigo, dizziness, psychosis, hallucinations, skin reactions, depression, dry mouth, sore throat, difficulty in micturition

DDI: Serious Pethidine causes fluctuating stupor, agitation, muscle rigidity, sweating & raised temperature, Dopamine increases BP, Combined hormonal contraceptives increases drug bioavailability, Moclobemide increases risk of hypotensive reactions, Nortriptyline/Amitriptyline leads to hypomania, Bupropion leads to orthostatic hypotension, Venlafaxine/Fluoxetine leads to serotonin syndrome

Diet: Before food

Monitor: BP, symptoms of parkinsonism, general mood & behavior, suicidal ideation

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