Sevelamer

Details About Generic Salt ::  Sevelamer 

Main Medicine Class:: Genito Urinary System   Sub Medicine Class ::  Drugs for Electrolyte Disturbances

10E. DRUGS FOR ELECTROLYTE DISTURBANCES in 10. GENITO-URINARY SYSTEM
SEVELAMER
PHOSPHATE BINDER | ANTIDOTE
PK: A: Not absorbed systemically E: Feces

Indications & Dose: HYPERPHOSPHATEMIA PO Adult Based on serum phosphorous levels: Initial dose: >5.5 to <7.5mg/dL: 800mg TID, >7.5 to <9.0mg/dL: 1.2-1.6g TID, >9mg/dL: 1.6g TID, MD: >5.5mg/dL: Increase by 400-800mg/meal at 2 wk intervals, 3.5-5.5 mg/dL: Same as initial dose, <3.5 mg/dL: Decrease by 400-800mg/mealCRF PATIENTS on HD

Contra: hypophosphatemia, bowel obstruction

Precautions: gi disorders

ADR: Serious: hypotension/ hypertension, peripheral edema, Others: diarrhea, nausea, vomiting, constipation, headache, cough, pruritus, intestinal obstruction

DDI: Serious Tacrolimus/Levothyroxine absorption is reduced, Quinolones bioavailability is reduced, Furosemide efficacy is abolished, Mycophenolate/Ciclosporin levels are reduced

Diet: With food

Monitor: Serum Phosphate, Ca, HCO3, cl-

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