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SIADH or Syndrome of inappropriate ADH (AVP)
- There is excessive secretion of AVP resulting in passage of decreased volume of highly concentrated urine.
- There is water retention and decrease in plasma sodium and plasma osmolarity.
- It is called dilutional hyponatraemia.
- It may be asymptomatic or there may be headacheHeadache. Read more ... », confusion, anorexia, nauseaNausea and Vomiting. Read more ... », vomitingNausea and Vomiting. Read more ... », coma and convulsions, death.
Causes of SIADH are:
- · Head injury
- · Neoplasms
- · Infections of lungs
- · Abscess
- · Encephalitis
- · TuberculosisLeprosy Hansen's Disease types Causes of leprosy sign and Symptoms With Treatment. Read more ... »
- · Cerebrovascular accidents
- · Multiple sclerosis
- · GB syndrome
- · Vasopressin
- · Oxytocin
- · Phenothiazines
- · Carbamazepines.
Treatment of SIADH
- Restriction of fluid intake to less than the loss through urine and insensible losses (sweat etc).
- The water intake from food is about 500 ml/day. Insens.ible loss is usually 500 ml/day.
- Liquid intake should be 500 mlless than the urinary output.
- IV infusion of hypertonic or 3% saline is given for rapid relief of symptomsChikungunya Virus Infection Diagnosis Clinical Signs and Symptoms withTreatment. Read more ... ».
- Very rapid correction of hyponatraemia should not be done as it can cause myelinolysis characterized by quadriparesis and ataxia.
- Demeclocycline (150-300 mg tidY.
- Fludrocortisone (0.05-0.2 mg orally bd).