Sibutramine

Details About Generic Salt ::  Sibutramine 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

8J. ANTI-OBESITY DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
SIBUTRAMINE
SYMPATHOMIMETIC | ANTI-OBESITY
PK: A: Rapid M: Hepatic E: Urine

Indications & Dose: OBESITY PO Adult Initially 10mg/day, may increase to 15mg/day after 4 wk as needed & tolerated max 15mg/day MD 5-15mg/day Child >16 yr: Same as adult dose & treatment should not be given for longer than 1 yr

Contra: Severe hepatic/renal impairment, anorexia nervosa, bulimia nervosa, uncontrolled/ poorly controlled HTN, history of cerebrovascular disease/CVD, bipolar disorder, Tourette’s syndrome, hyperthyroidism, pheochromocytoma, BPH, history of drug/alcohol abuse

Precautions: well-controlled HTN, mild-to- moderate renal impairment, glaucoma, patients with a history of depression, seizures/gallstones

ADR: Serious: HTN, abnormal bleeding, thrombocytopenia, ARF, seizures, blurred vision, flu-like symptoms, Others: headache, insomnia, constipation, diarrhea, back pain, increased appetite, dizziness, anxiety, drowsiness, nervousness

DDI: Serious SSRIs/MAOIs causes serotonin syndrome, Azoles increases drug levels, Dihydroergotamine/Dextromethorphan/Fentanyl/Pentazocine/Pethidine/Sumatriptan/Tryptophan/Venlafaxine leads to serotonin syndrome

Diet: With/without food (low calorie diet preferred)

Monitor: Weight, waist circumference, BP, HR

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