Stavudine

Details About Generic Salt ::  Stavudine 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Anti Retrovirals (Drugs for HIV)

13N. ANTI-RETROVIRALS (DRUGS FOR HIV) in 13. ANTI-INFECTIVES
STAVUDINE
NRTI | ANTIRETROVIRAL
PK: A: Rapid M: Hepatic E: Urine

Indications & Dose: HIV INFECT PO Adult >60 kg: 40mg q12h, <60 kg: 30mg q12h Child Neonates(birth-13 days): 500µg/kg q12h, >14 days (<30 kg): 1mg/kg q12h, >30 kg: 40mg q12h

Contra: Hypersensitivity, lactic acidosis, hyperlactatemia

Precautions: history of peripheral neuropathy, hepatomegaly, renal disease, bone marrow depression, pancreatitis, HIV infect

ADR: Serious: hyperbilirubinemia, peripheral neuropathy, increases liver enzymes, lactic acidosis, osteonecrosis, convulsions, Others: diarrhea, dyspepsia, depression, headache, fatigue, insomnia, rash, pruritus, sleep disturbances, nausea

DDI: Serious Zidovudine/Doxorubicin inhibits drug effects, Didanosine leads to peripheral neuropathy & pancreatitis, Chlorpropamide level is reduced

Diet: With/without food

Monitor: LFT, renal function tests, signs & symptoms of peripheral neuropathy, viral load & CD4 count

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