Tenofovir

Details About Generic Salt ::  Tenofovir 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

13N. ANTI-RETROVIRALS (DRUGS FOR HIV) in 13. ANTI-INFECTIVES
TENOFOVIR
NUCLEOSIDE ANALOG REVERSE TRANSCRIPTASE INHIBITOR | ANTI-RETROVIRAL
PK: A: Rapid D: 1.2-1.3L/kg (Vd) M: Hepatic E: Urine

Indications & Dose: CHRONIC HEPATITIS B INFECT PO Adult 300mg OD as disoproxil fumarate ester | HIV INFECTION & AIDS PO Adult 300mg OD as disoproxil fumarate ester

Contra: Concurrent/recent nephrotoxic therapy, concurrent use of didanosine

Precautions: Renal impairment, lactic acidosis, exacerbation of hepatitis, hepatomegaly with steatosis, elderly

ADR: Serious: increases TG level, chest pain, hematuria, pneumonia, lactic acidosis, Others: URTI, fatigue, serum amylase increases, insomnia, dizziness, rash, nausea, diarrhea, vomiting, weakness

DDI: Serious Vancomycin enhances nephrotoxicity, HIV protease inhibitors increases drug levels, Didanosine increases risk of pancreatitis & peripheral neuropathy

Diet: With/without food

Monitor: Patients with HIV: CBC, reticulocyte count, SeCr, CD4 count, HIV RNA plasma levels, renal and LFTs, bone density. Patients with HBV: HIV status, bone density, serum phosphorus, SeCr, LFTs, signs/symptoms of HBV relapse/exacerbation

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