Terbinafine

Details About Generic Salt ::  Terbinafine 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Anti Fungals

13I. ANTI-FUNGALS in 13. ANTI-INFECTIVES
TERBINAFINE
ALLYLAMINE DERIVATIVE | ANTIFUNGAL
also comes under 15C. Anti-Microbials (Fungal, Parasites, Viral) in 15. Skin
PK: A: >70% D: 1000L (Vd) M: Hepatic E: Urine

Indications & Dose: CUTANEOUS CANDIDIASIS TP Adult Cream/gel/solution containing 1% terbinafine hydrochloride is to apply OD or BID 2 wks | DERMATOPHYTE INFECT PO Adult Nail infect: 250mg OD 6-12 wks, longer treatment may require for toe-nail infect Child >1 yr: 10-20 kg: 62.5mg OD, 20-40 kg: 125mg OD, >40 kg: 250mg OD 6 wks-3 months, longer treatment may require for toe-nail infect | PITYRIASIS VERSICOLOR TP Adult Cream/gel/solution containing 1% terbinafine hydrochloride is applied OD or OD 2 wks | TINEA CAPITIS PO Child >1 yr: 10-20 kg: 62.5mg OD, 20-40 kg: 125mg OD, >40 kg: 250mg OD 4 wks | TINEA CORPORIS PO Adult 250mg OD 4 wk Child >1 yr: 10-20 kg: 62.5mg OD, 20-40 kg: 125mg OD, >40 kg: 250mg OD 4 wks | TP Adult Cream/gel/solution containing 1% terbinafine hydrochloride is applied OD or BID 1-2 wks | TINEA CRURIS PO Adult 250mg OD 2-4 wks Child >1 yr: 10-20 kg: 62.5mg OD, 20-40 kg: 125mg OD, >40 kg: 250mg OD 2-4 wks | TP Adult Cream/gel/solution containing 1% terbinafine hydrochloride is applied OD or BID 1-2 wks | TINEA PEDIS PO Adult 250mg OD 6 wks Child >1 yr: 10-20 kg: 62.5mg OD, 20-40 kg: 125mg OD, >40 kg: 250mg OD 6 wks | TP Adult Cream/gel/solution containing 1% terbinafine hydrochloride is applied OD or BID 1 wk

Contra: hypersensitivity, hepatic impairment

Precautions: psoriasis, sensitive to allylamine antifungals

ADR: Serious: SJS, TEN, liver dysfunction, angioedema, blood disorders, Others: fever, local reactions, photosensitivity, paraesthesia, dizziness, depression, GI disturbances, loss/disturbance of taste, headache, myalgia, skin reactions

DDI: Serious Warfarin anticoagulant effect is increased/decreased, Mexiletine/Flecainide/Propafenone increases drug levels, Carbamazepine leads to fatal TEN, SSRIs levels are modestly increased, Rifampicin reduces drug plasma levels, TCAs serum levels are increased

Diet: With/without food

Monitor: AST/ALT, CBC

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