Terfenadine

Details About Generic Salt ::  Terfenadine 

Main Medicine Class:: Immunology , Allergy   Sub Medicine Class ::  Anti Allergics

6B. ANTI-HISTAMINES AND NASAL DECONGESTANTS in 6. RESPIRATORY SYSTEM
TERFENADINE
NON-SEDATIVE ANTI-HISTAMINE | ANTI-ALLERGIC
also comes under 14C. Anti-Allergics in 14. Immunology & Allergy
PK: A: Rapid M: Hepatic E: Urine & feces

Indications & Dose: ALLERGIC CONDITIONS/URTICARIA PO Adult 120mg/day or 60mg BID or 120mg in morning Child >12 yr & >50 kg: Same as adult dose | RHINITIS PO Adult 60mg/day single dose or in 2 divided doses Child >12 yr & >50 kg: Same as adult dose

Contra: Porphyria

Precautions: History of cardiac/hepatic diseases, QT prolongers, drugs causes electrolyte imbalance

ADR: Serious: acute hepatitis, jaundice, angioedema, palpitations, ventricular arrhythmias, Torsade de pointes, Others: alopecia, photosensitivity, anxiety, insomnia, skin reactions, rashes, urticaria

DDI: Serious Paracetamol causes Torsade de pointes, Verapamil/Nifedipine increases adverse effects, Aprepitant increases risk of life-threatening Torsade de pointes arrhythmias, Flecainide increases the risk of ventricular arrhythmias, Fluoxetine leads to cardiotoxicity, Amphotericin-B leads to hypokalemia, Azoles leads to life-threatening arrhythmias, Zafirlukast level is reduced, Macrolides prolongs QT interval & life-threatening torsade de pointes arrhythmias, Laxatives/Corticosteroids/Loop diuretics/Thiazides results in hypokalemia, Carbamazepine toxicity occurs

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