Thioguanine

Details About Generic Salt ::  Thioguanine 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
THIOGUANINE
2-AMINOPURINE | ANTI-NEOPLASTIC
PK: A: 30% M: Hepatic E: Urine

Indications & Dose: ACUTE MYELOID LEUKEMIA PO Adult 100-200mg/m2/day, increased the dose of 2mg/kg/day after 4 wk Child 100-200mg/m2/day

Contra: Hypersensitivity

Precautions: Renal/hepatic impairment, patients on vaccination

ADR: Serious: hepatotoxicity, myelosuppression, secondary malignancies, tumor lysis syndrome, fluid retention, hyperuricemia, intestinal necrosis, intestinal perforation, splenomegaly, hematologic disorders, infect, Others: stomatitis, vomiting, nausea, anorexia

DDI: Serious Busulfan leads to nodular regenerative hyperplasia of liver, portal HTN & esophageal varices, Phenytoin/Carbamazepine/Valproic acid levels are reduced

Monitor: CBC, LFTs, serum uric acid, test for TPMT deficiency

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