Tibolone

Details About Generic Salt ::  Tibolone 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Progestins and Anti Progestins

8G. PROGESTINS AND ANTI-PROGESTINS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
TIBOLONE
ESTROGEN & PROGESTOGEN COMBINATION
PK: A: Rapid & extensive E: Bile, feces & urine

Indications & Dose: HOT FLUSH & SWEATING Symptomatic therapy PO Adult 2.5mg OD continue at least 3 months to achieve optimal response | PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS PO Adult 2.5mg OD continue at least 3 months to achieve optimal response

Contra: CVD, cerebrovascular disorders, history of hormone dependent tumors, severe liver disorders, porphyria, untreated endometrial hyperplasia, undiagnosed vaginal bleeding, premenopausal women

Precautions: Endometriosis, uterine fibroids, renal dysfunction, cardiac dysfunction, DM, epilepsy, migraine, history of dyslipidemia

ADR: Serious: myalgia, arthralgia, leucorrhea, candidiasis, vaginitis, irregular vaginal bleeding, breast cancer, liver dysfunction, visual disturbances, Others: weight gain, dizziness, skin reactions, headache, GI disturbances, hypertrichosis, depression

DDI: Serious Antidiabetics impairs glucose tolerance, Warfarin increases INR

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