Ticlopidine

Details About Generic Salt ::  Ticlopidine 

Main Medicine Class:: Hematological System   Sub Medicine Class ::  Anti Platelets

5A. ANTI-PLATELETS in 5. HEMATOLOGICAL SYSTEM
TICLOPIDINE
PLATELET AGGREGATION INHIBITOR | ANTI-PLATELET
PK: A: Well absorbed M: Hepatic E: Urine & feces

Indications & Dose: INTERMITTENT CLAUDICATION PO Adult 250mg BID | PREVENTION OF SUBACUTE STENT OCCLUSION PO Adult 250mg BID for 28 days from the beginning of stent placementAfter intracoronary stenting | THROMBOTIC STROKE PO Adult 250mg BID to reduce risk of fatal/non-fatal stroke

Contra: hypersensitivity, active pathological bleeding, severe hepatic impairment, hematopoietic disorders, elderly

Precautions: mild-to-moderate hepatic impairment, moderate-to-severe renal impairment, anticoagulants & platelet aggregation inhibitors

ADR: Serious: hematologic toxicity, Increases TC level, angioedema, hematuria, risk of bleeding, Others: diarrhea, rash, nausea, dyspepsia, GI pain, ALP increases

DDI: Serious Theophylline clearance is reduced, Aspirin increases bleeding risk, Warfarin increases bleeding risk, & cholestatic hepatitis, Phenytoin toxicity occurs

Diet: With food

Monitor: CBC, TTP, LFTs

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