Timolol

Details About Generic Salt ::  Timolol 

Main Medicine Class:: Ocular   Sub Medicine Class ::  Anti Glaucoma Drugs

3A. ANTI-GLAUCOMA DRUGS in 3. OCULAR
TIMOLOL
NON-SELECTIVE ß-ADRENERGIC BLOCKER | ANTI-GLAUCOMA
PK: A: 90% (PO) M: Liver (PO) E: Urine (PO)

Indications & Dose: OCULAR HYPERTENSION TP Adult Initially instill 1 drop (0.25% solution) into affected eye(s) BID, if no response increase to 0.5% solution max 1 drop BID. Gel-forming solution: Instill 1 drop (0.25% or 0.5% solution) OD | OPEN-ANGLE GLAUCOMA TP Adult Initially instill 1 drop (0.25% solution) into affected eye(s) BID, if no response increase to 0.5% solution max 1 drop BID. Gel-forming solution: Instill 1 drop (0.25% or 0.5% solution) OD

Contra: hypersensitivity, sinus bradycardia, sinus node dysfunction, heart block, cardiogenic shock, uncompensated HF, bronchospasm/asthma, COPD, metabolic acidosis, hypotension, Prinzmetal’s angina

Precautions: DM, HF, myasthenia gravis, PVD, pheochromocytoma, psoriasis, psychiatric disease, renal impairment, first-degree heart block, during drug withdrawal

ADR: Serious: bronchospasm, shortness of breath & dyspnea, worsen cardiac disorders, pneumonitis, Raynaud’s syndrome, HF, heart block, blurred vision, hematological reactions, SLE, Others: coldness of extremities, nausea, vomiting, diarrhea, rash, headache, depression, dizziness, fatigue, myopathy

DDI: Serious Quinidine can cause bradycardia (eye drops), Aspirin increases BP, Flecainide results in bradycardia

Diet: With food

Monitor: BP, apical & radial pulses, fluid I & O, weight, respirations, mental status

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