Tirofiban

Details About Generic Salt ::  Tirofiban 

Main Medicine Class:: Hematological System   Sub Medicine Class ::  Anti Platelets

5A. ANTI-PLATELETS in 5. HEMATOLOGICAL SYSTEM
TIROFIBAN
GLYCOPROTEIN IIB/IIIA-RECEPTOR INHIBITOR | ANTI-PLATELET
PK: M: Hepatic E: Urine, bile & feces

Indications & Dose: UNSTABLE ANGINA/NON-ST-SEGMENT-ELEVATION MYOCARDIAL INFARCTION IV Adult Loading dose 0.4µg/kg/min up to 30min after diagnosis, followed by inf of 0.1µg/kg/min 1-2 days. PCI patients: Loading dose 0.4µg/kg/min up to 30min followed by continuous inf of 0.1µg/kg/min during angiography & for 12-24h after angiography/atherectomy

Contra: Hypersensitivity, history of bleeding diathesis, history of intracranial hemorrhage, intracranial neoplasm, history of thrombocytopenia, history of hemorrhagic stroke, acute pericarditis, severe HTN

Precautions: percutaneous coronary intervention, platelet counts (<150, 000/mm3), hemorrhagic retinopathy, chronic dialysis patients, previous history of GI disease, renal impairment, elderly, recent thrombolytic therapy

ADR: Serious: bleeding, coronary artery dissection, anaphylaxis, bradycardia, Others: edema, dizziness, vasovagal reaction, fever, headache, rash, nausea, diaphoresis, pelvic pain

DDI: Serious Heparin/Enoxaparin increases risk of bleeding

Monitor: Platelet count,vital signs,signs of unusual or excessive bleeding

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