Tizanidine

Details About Generic Salt ::  Tizanidine 

Main Medicine Class:: Musculoskeletal Disorders , Pain   Sub Medicine Class ::  Skeletal Muscle Relaxants

12A. SKELETAL MUSCLE RELAXANTS in 12. MUSCULOSKELETAL DISORDERS & PAIN
TIZANIDINE
A-ADRENERGIC AGONIST | SKELETAL MUSCLE RELAXANT
PK: A: Well absorbed M: Hepatic E: Urine

Indications & Dose: SPASTICITY PO Adult Initially 4mg, may increase 2-4mg q6-8h, max 3doses/day

Contra: Hypersensitivity, ciprofloxacin/fluvoxamine, other CYP1A2 inhibitors

Precautions: hypotension, renal/hepatic impairment, CNS depressants, elderly, abrupt withdrawal

ADR: Serious: hypotension, UTI, pharyngitis, rhinitis, liver enzymes increased, myasthenia gravis, Others: nervousness, speech disorder, visual hallucinations, skin ulcer, rash, dyskinesia, paresthesia, blurred vision, flu-like syndrome, constipation, vomiting, abdominal pain, dyspepsia, diaphoresis, infect

DDI: Serious Lisinopril causes severe hypotension, Amiodarone/Aciclovir/Cimetidine/Famotidine/Hormonal Contraceptives/Mexiletine/Propafenone/Ticlopidine/Verapamil increases adverse effects, Fluvoxamine/Ciprofloxacin increases hypotensive & sedative effects of drug, Diuretics leads to bradycardia & hypotension

Diet: With/without food

Monitor: Vital signs, LFT

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