Tolvaptan

Details About Generic Salt ::  Tolvaptan 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

10E. DRUGS FOR ELECTROLYTE DISTURBANCES in 10. GENITO-URINARY SYSTEM
TOLVAPTAN
BENZAZEPINE DERIVATIVE | VASOPRESSIN RECEPTOR V2 ANTAGONIST

Indications & Dose: EUVOLEMIC/HYPERVOLEMIC HYPONATREMIA PO Adult 15mg OD, dosage may be increased to 30mg OD at an interval of at least 24h, max 60mg OD to achieve serum sodium concentration

Contra: Patients who require urgent intervention to acutely raise serum sodium concentration, inability of the patient to sense or appropriately respond to thirst, hypovolemic hyponatremia, anuria, concomitant use of potent inhibitors of CYP450 isoenzyme

Precautions: Avoid fluid restrictions during the first 24 h of therapy, concomitant use with hypertonic sodium chloride is not recommended, safety and efficacy not established in children <18 years, advise that may continue to take drinking fluids in response to thirst

ADR: Serious: Osmotic demyelination, dysarthria, mutism, lethargy, dysphagia, spastic quadriparesis, GI bleeding in patients with cirrhosis, dehydration and hypovolemia, hyperkalemia, Others: thirst, dry mouth, polyuria, asthenia, constipation, hyperglycemia, pyrexia, anorexia

DDI: Serious Ciclosporin increases drug levels, Diuretics increases the risk of dehydration and hypovolemia with the concurrent use of drug, Lovastatin levels modestly increases by drug, Rifampicin/CYP3A4 Inducers reduces the drug exposure, Potassium-sparing diuretics/ACEIs slightly increases the risk of hyperkalemia with drug

Monitor: Serum sodium concentration, Serum potassium concentration,neurologic status

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