Trifluoperazine

Details About Generic Salt ::  Trifluoperazine 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Anti Psychotics

1E. ANTI-PSYCHOTICS in 1. NERVOUS SYSTEM
TRIFLUOPERAZINE
D1/D2 RECEPTOR BLOCKER | TYPICAL ANTI-PSYCHOTIC
PK: A: Rapid D: Extensive M: Hepatic

Indications & Dose: NON-PSYCHOTIC ANXIETY PO Adult 1-2mg BID max 6mg/day 12 wk Elderly Start with low dose | SCHIZOPHRENIA/PSYCHOSES PO Adult Outpatients: 1-2mg BID, hospitalized/well-supervised patients: Initially 2-5mg BID with optimum response range 15-20mg/day max 40mg/day Child 6-12 yr: Hospitalized/well-supervised patients: Initially 1mg OD/BID, may increase dose until symptoms controlled max 15mg/day Elderly Start with low dose

Contra: Hypersensitivity, severe CNS depression, bone marrow suppression, blood dyscrasias, severe hepatic disease, coma

Precautions: seizures, CVD, GI obstruction, glaucoma, elderly

ADR: Serious: jaundice, adynamic ileus, NMS, hypotension, QT interval prolongation, torsades de pointes, tachycardia, peripheral edema, blurred vision, glycosuria, amenorrhea, gynecomastia, Others: allergic reactions, blood disorders, sedation, drowsiness, insomnia, fatigue, anorexia, urinary retention, constipation, drymouth, muscle weakness, weight gain

DDI: Serious Lithium can lead to neurotoxicity, Alcohol causes acute extrapyramidal adverse effects, MAOIs leads to neuroleptic malignant syndrome or hyperpyrexia

Diet: With food

Monitor: Vital signs,lipid profile,fasting blood glucose/Hgb A1c; mental status,abnormal involuntary movement scale

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