Trihexyphenidyl

Details About Generic Salt ::  Trihexyphenidyl 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Drugs for Neurodegenerative Disorders

1F. DRUGS FOR NEURODEGENERATIVE DISORDERS in 1. NERVOUS SYSTEM
TRIHEXYPHENIDYL
ANTI-CHOLINERGIC | ANTI-PARKINSONIAN
PK: A: Well absorbed M: Hepatic E: Urine & bile

Indications & Dose: DRUG INDUCED EXTRAPYRAMIDAL SYMPTOMS PO Adult Initially 1mg/day, increase as required. Usual range 5-15mg/day in 3-4 divided doses | PARKINSON’S DISEASE PO Adult Initially 1mg/day, increases by 2mg at an interval of 3-5 days, usual dose 6-10mg/day in 3-4 divided doses, max15mg/day Elderly Same as adult dose

Precautions: CVD, history of GI obstruction, renal/hepatic impairment, glaucoma, patients with prostatic hyperplasia and/or urinary stricture

ADR: Serious: tachycardia, blurred vision, glaucoma, Increased IOP, mydriasis, Others: constipation, dilatation of colon, nausea, vomiting, xerostomia, parotitis, urinary retention, rash

DDI: Serious Imipramine causes atropine-like psychoses, Fluphenazine/Chlorpromazine leads to heat stroke, Levodopa levels are decreased

Diet: With food

Monitor: IOP, gonioscopic evaluations performed periodically

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