Valaciclovir

Details About Generic Salt ::  Valaciclovir 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

13M. ANTI-VIRALS (NON RETROVIRAL) in 13. ANTI-INFECTIVES
VALACICLOVIR
PURINE NUCLEOSIDE ANALOG | ANTI-VIRAL
PK: A: Rapid D: Extensive M: Hepatic E: Urine

Indications & Dose: CHICKENPOX PO Child 2-17 yr: 20mg/kg/dose TID 5 days, max 1g TID | GENITAL HERPES PO Adult 1gm BID 10 days for initial episode, 500mg BID 3 days for recurrent episodes, 500mg/day is taken by the infected partner to reduce transmission | HERPES ZOSTER PO Adult 1g TID 7 days | SUPPRESSION OF HERPES SIMPLEX INFECT PO Adult 500mg/day in 1-2 divided doses (immunocompetent)

Contra: Hypersensitivity, pediatrics

Precautions: Renal impairment, elderly

ADR: Serious: neutropenia, increased LFTs, thrombocytopenia, herpes simplex, hypersensitivity reactions, delirium, erythema multiforme, TTP, tremor, Others: agitation, alopecia, arthralgia, rhinorrhea, headache, nausea, nasopharyngitis, fatigue, depression, dizziness, rash, dysmenorrhea, vomiting, diarrhea

DDI: Serious Cimetidine increases AUC of valaciclovir, Mycophenolate neutropenia, Probenecid reduces renal excretion & increases valaciclovir plasma levels

Diet: With food

Monitor: Urinalysis, BUN, SeCr, LFTs, CBC

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