Valganciclovir

Details About Generic Salt ::  Valganciclovir 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

13M. ANTI-VIRALS (NON RETROVIRAL) in 13. ANTI-INFECTIVES
VALGANCICLOVIR
SYNTHETIC GUANINE DERIVATIVE | ANTI-VIRAL
PK: A: Well absorbed D: 0.7 L/kg (Vdss) M: Hepatic E: Urine

Indications & Dose: CYTOMEGALOVIRUS RETINITIS PO Adult Induction: 900mg BID 21 days | PO Adult Maintenance: 900mg OD | PREVENTION OF CYTOMEGALOVIRUS RETINITIS IN ORGAN TRANSPLANT RECIPIENTS PO General 900mg OD 10 days before transplantation & continue for 100 days (heart/kidney-pancreas transplant) or 200 days (kidney transplant) post-transplantation

Contra: Hypersensitivity

Precautions: renal impairment, nephrotoxic agents, elderly, liver transplant recipients, history of pre-existing bone marrow suppression, history of cytopenias, myelosuppressive drugs

ADR: Serious: HTN, tremor, peripheral edema, blood disorders, renal impairment, nasopharyngitis, arthralgia, bone marrow depression, hypokalemia, seizures, URTI, retinal detachment, Others: dysuria, back pain, muscle cramps, dyspnea, UTI, abdominal pain, hyperglycemia, cough, agitation, dermatitis, confusion, nausea, vomiting, fever, headache, insomnia, constipation

DDI: Serious Mycophenolate causes neutropenia, Tenofovir causes renal failure & nephrotoxicity, Zidovudine increases hematological toxicity, Trimethoprim increases risk of myelosuppression, Imipenem leads to generalized seizures, Didanosine level raised, Probenecid reduces renal excretion

Diet: With food

Monitor: Retinal exam, CBC, platelet counts, SeCr

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