Vardenafil

Details About Generic Salt ::  Vardenafil 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

11B. DRUGS FOR ERECTILE DYSFUNCTION/LIBIDO/INFERTILITY in 11. REPRODUCTIVE SYSTEM
VARDENAFIL
PDE-5-INHIBITOR | ANTI-ERECTILE DYSFUNCTION DRUG
PK: A: Rapid D: 208 L (Vd) M: Hepatic E: Feces (91%) & urine (2%)

Indications & Dose: ERECTILE DYSFUNCTION PO Adult 10mg 1h before sexual activity Elderly > 65 yrs: Initially 5mg 1h before sexual activity

Contra: Hypokalemia, congenital QT prolongation, antiarrhythmics class Ia/class III, concurrent use of organic nitrates, hypersensitivity, CVD, other treatments for erectile dysfunction

Precautions: hepatic/renal impairment, retinitis pigmentosa, left ventricular outflow obstruction, anatomical deformation of penis, bleeding disorders, PUD, a-blockers, elderly

ADR: Serious: prolongs QT interval, flushing, anaphylactic reaction, angioedema, blurred vision, chest pain, dyspnea, erythema, syncope, Others: gastritis, xerostomia, diarrhea, arthralgia, headache, dizziness, dyspepsia, nausea, back pain, rhinitis, nasal congestion, abdominal pain, photosensitivity

DDI: Serious Verapamil/Diltiazem inhibits vardenafil metabolism, Azoles markedly raises vardenafil levels, Rifampicin markedly reduces vardenafil levels, HIV protease inhibitors markedly rises sildenafil levels, Terazosin/Doxazosin postural hypotension, Nitrates potentially serious hypotension/precipitate MI, Erythromycin/Clarithromycin raises vardenafil levels, Sodium nitroprusside severe hypotension, Procainamide/Amiodarone/Quinidine/Sotalol significantly prolongs QT interva

Diet: With/without food, 60 min before sexual activity

Monitor: ADR, BP, HR

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