Vecuronium

Details About Generic Salt ::  Vecuronium 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Miscellaneous

16C. MISCELLANEOUS in 16. ANESTHETICS
VECURONIUM
NEUROMUSCULAR BLOCKER (NON-DEPOLARIZING) | SKELETAL MUSCLE RELAXANT
PK: D: 0.3-0.4 L/kg (Vd) M: Hepatic (partly metabolized) E: Feces (40-75%) & urine (30% as unchanged drug & metabolite)

Indications & Dose: MUSCLE RELAXATION DURING SURGERY IV Adult Inf: Initially 40–100µg/kg, then 0.8–1.4µg/kg/min | TRACHEAL INTUBATION IV Adult Initially 0.08-0.1mg/kg, reduce dose to 0.04-0.06mg/kg when used with succinylcholine & 0.05-0.06mg/kg with balanced anesthesia Child 1–4 month: Initially 0.01-0.02mg/kg followed by incremental doses according to response, 5 month: Same as adult dose

Contra: Hypersensitivity, dehydrated/severely ill patients, myasthenia gravis/other neuromuscular disorders, respiratory insufficiency/pulmonary disease

Precautions: Hepatic/renal impairment, burns patients, anephric patients, underlying respiratory disease, previous anaphylactic reaction, elderly, children 1-10 yr, electrolyte disturbances, respiratory acidosis/hypokalemia, history of asthma, severe obesity

ADR: Serious: Acute quadriplegic myopathy syndrome, bradycardia, circulatory collapse, myositis ossificans, hypersensitivity reactions, Others: itching

DDI: Serious GA causes bradycardia particularly in presence of an opioid, Magnesium sulphate increases & prolongs drug effect, Ciclosporin increases neuromuscular blocking effects drug, Cimetidine may slightly prolong drug effects, Testosterone shows marked resistance to the drug effects

Monitor: BP, HR, peripheral nerve stimulation