Vinorelbine

Details About Generic Salt ::  Vinorelbine 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
VINORELBINE
VINCA ALKALOID | ANTI-NEOPLASTIC
PK: A: Rapid D: Extensive M: Hepatic E: feces via bile, urine

Indications & Dose: NON-SMALL CELL LUNG CANCER IV Adult 30mg/m2/dose q7days | Combination therapy IV Adult 25-30mg/m2/dose q7days with cisplatin

Contra: Pretreatment granulocyte counts

Precautions: Bone marrow suppression, history of radiation therapy, patients with neurotoxicity, hepatic impairment

ADR: Serious: peripheral neuropathy, paralytic ileus, ototoxicity, dyspnea, thrombocytopenia, neutropenic fever, Others: vomiting, Inj site reaction includes erythema, vein discoloration, fatigue, alopecia, nausea, constipation, diarrhea, increased total bilirubin

DDI: Serious Mitomycin acute pulmonary toxicity, Cisplatin increases risk of granulocytopenia, Itraconazole increasing vinorelbine toxicity, Rifampicin vinorelbine reduces rifampicin levels

Monitor: CBC,platelet count,hepatic function tests,new-onset pulmonary symptoms,neuropathy

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