Zaleplon

Details About Generic Salt ::  Zaleplon 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

1A. SEDATIVES & HYPNOTICS in 1. NERVOUS SYSTEM
ZALEPLON
NON-BENZODIAZEPINE | SEDATIVE, HYPNOTIC
PK: A: Rapid & complete D: 1.4 L/kg (Vd) M: Hepatic E: Urine (70%) & feces (17%)

Indications & Dose: INSOMNIA Short-term therapy PO Adult 10mg HS Elderly 5mg HS

Contra: Hypersensitivity, sleep apnea syndrome, myasthenia gravis, severe hepatic impairment, prolonged therapy

Precautions: Respiratory insufficiency, muscle weakness, history of drug/alcohol abuse, depression

ADR: Serious: Anaphylaxis, angioedema, complex sleep-related behaviour, hypersensitivity reactions, cholelithiasis, facial paralysis, ventricular tachycardia, hypo/hypertension, respiratory depression, urinary retention/incontinence, sedation, Others: paradoxical excitation, visual disturbances, libido, GI disturbances, tremor, amnesia, drowsiness, muscle weakness, ataxia, vertigo, headache, confusion, depression, slurred speech, blood disorders, thrombophlebitis, dysarthria

DDI: Serious Phenobarbital/Carbamazepine/Phenytoin reduces drug efficacy Others Rifampicin decreases drug level, Alcohol enhances CNS depression, CNS Depressants increases CNS depression

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