Zolpidem

Details About Generic Salt ::  Zolpidem 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Sedatives , Hypnotics

1A. SEDATIVES & HYPNOTICS in 1. NERVOUS SYSTEM
ZOLPIDEM
SELECTIVE BENZODIAZEPINE RECEPTOR AGONIST | SEDATIVE, HYPNOTIC
PK: A: Rapid D: 0.54L/Kg (Vd) M: Hepatic E: Urine (48-67%), Feces (29-49%)

Indications & Dose: INSOMNIA PO Adult IR tablet/sublingual tablet/spray: 10mg HS max 10mg, ER tablet: 12.5mg HS Elderly IR tablet/sublingual tablet/spray: 5mg HS; ER tablet: 6.25mg HS

Contra: Hypersensitivity to zolpidem, obstructive sleep apnea, acute/severe respiratory depression, myasthenia gravis, severe hepatic impairment, psychotic illness, long-term therapy

Precautions: Depression, muscle weakness, history of drug /alcohol abuse, renal impairment, elderly

ADR: Serious: Chest discomfort/pain, palpitation, arthritis, bronchitis, arthralgia, urticaria, CVD, hepatic function abnormalities, hyper/hypotension, leukopenia, lymphadenopathy, migraine, tongue paresthesia, ARF, vaginitis, tachycardia, anaphylaxis, angioedema, complex sleep-related behavior, UTI, thrombosis, menstrual disorder, visual disturbance, urinary incontinence, Others: Anemia, rash, abnormal dreams, anxiety, myalgia, abdominal pain, constipation, nausea, vomiting, URTIs

DDI: Serious CNS Depressants/Alcohol increases CNS depressant effects of drug, Ritonavir increases drug level Others Rifampicin/Alcohol decreases drug level

Diet: After food

Monitor: Daytime alertness, respiratory rate, behavior profile, LFTs

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