Zonisamide

Details About Generic Salt ::  Zonisamide 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Anti Epileptics

1C. ANTI-EPILEPTICS in 1. NERVOUS SYSTEM
ZONISAMIDE
SULFONAMIDE | ANTI-EPILEPTIC
PK: A: Rapid D: 1.45L/kg (Vd) M: Hepatic E: Urine

Indications & Dose: PARTIAL SEIZURES WITH/ WITHOUT SECONDARY GENERALIZATION Adjuvant therapy PO Adult Initially 50mg/day in 2 divided doses, increase after 1wk to 100mg/day in 2 divided doses, may be increase by 100mg q7days, MD 300-500mg/day in 1–2 divided doses

Contra: Hypersensitivity

Precautions: Hepatic/renal impairment, elderly, concomitant use of drugs that increase risk of hyperthermia or nephrolithiasis, avoid abrupt withdrawal

ADR: Serious: SJS, TEN, hepatitis, rhabdomyolysis, hypokalemia, convulsions, pancreatitis, NMS, Others: nausea, vomiting, abdominal pain, paresthesia, diarrhea, dizziness, drowsiness, confusion, ataxia, anorexia, diplopia, dyspnea, insomnia, hallucinations, pruritus

Diet: With/without food

Monitor: BUN, Serum bicarbonate & suicidality

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