Zuclopenthixol

Details About Generic Salt ::  Zuclopenthixol 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Anti Psychotics

1E. ANTI-PSYCHOTICS in 1. NERVOUS SYSTEM
ZUCLOPENTHIXOL
D1/D2 RECEPTOR ANTAGONIST | TYPICAL-ANTIPSYCHOTIC
PK: A: Well absorbed D: Vd: 15-20L/kg M: Liver E: Feces

Indications & Dose: SCHIZOPHRENIA PO Adult Initially 10-50mg/day in 2-3 divided doses, MD 20-40mg/day max 100mg/day | IM Adult 50-150mg (as acetate) may be repeated in 2-3 days, do not give more than 4 inj during treatment course max 400mg during treatment course

Contra: Hypersensitivity, severe CNS depression, coma, suspected/established subcortical brain damage, circulatory collapse, blood dyscrasias, pheochromocytoma, acute intoxication, QT prolongation, bone marrow suppression

Precautions: severe CVD, narrow angle glaucoma, hepatic impairment, myasthenia gravis, parkinson’s disease, respiratory disease, seizure disorder, children, CNS depression, decreased GI motility, paralytic ileus, urinary retention, BPH, xerostomia, visual problems, risk of pneumonia, strenuous exercise, heat exposure, dehydration

ADR: Serious: blurred vision, mydriasis, tachycardia, ECG changes, cardiac arrhythmias, orthostatic hypotension, delirium, NMS, convulsions, hypersensitivity reactions, jaundice, hematological disorders, hyperprolactinemia, extrapyramidal dysfunction, Others: weight gain, hyperglycemia, altered glucose tolerance, pain & irritation, photosensitivity reactions, impotence, somnolence, dry mouth, constipation, difficulty with micturition, agitation, catatonic-like states, insomnia, drowsiness, depression

DDI: Serious Lithium causes neurotoxicity, Moclobemide increases adverse effects, Antidiabetics increases risk of glucose intolerance, Alcohol leads to CNS depression

Monitor: Vital signs; lipid profile, fasting blood glucose, Hgb A1c, BMI, mental status, EPS

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