Article Contents ::
Details About Generic Salt :: Tetrabenazine
Main Medicine Class:: Nervous System Sub Medicine Class :: Drugs for Neurodegenerative Disorders
| 1F. DRUGS FOR NEURODEGENERATIVE DISORDERS in 1. NERVOUS SYSTEM |
| TETRABENAZINE |
| CENTRAL MONOAMINE-DEPLETING AGENT |
| PK: A: Poor & erratic M: Hepatic E: Urine |
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Indications & Dose: TARDIVE DYSKINESIA Moderate-to-severe PO Adult Initially 12.5mg/day, subsequently titrated according to response | TREATMENT OF CHOREA ASSOCIATED WITH HUNTINGTON’S DISEASE PO Adult Initially 12.5mg OD, may increase to 12.5mg BID after a wk. MD may increase to 12.5mg/day at weekly intervals; doses >37.5mg/day should be divided into 3doses |
| Precautions: should not drive or operate machinery
ADR: Serious: orthostatic hypotension, symptoms of extrapyramidal dysfunction, NMS, parkinsonism, Others: GI disturbances, depression, Drowsiness DDI: Others MAOIs causes depression, confusion, restlessness, disorientation, Levodopa effects reduces |