Article Contents ::
Details About Generic Salt :: Trazodone
Main Medicine Class:: Nervous System Sub Medicine Class :: Anti Depressants
| 1D. ANTI-DEPRESSANTS in 1. NERVOUS SYSTEM |
| TRAZODONE |
| SEROTONIN REUPTAKE INHIBITOR | ANTI-DEPRESSANT, ANXIOLYTIC |
| also comes under 1B. Anxiolytics in 1. Nervous System |
| PK: A: Well absorbed M: Hepatic E: Urine |
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Indications & Dose: ANXIETY PO Adult Initially 75mg/day, total daily dosage may be increased by 50mg q3 or 4 days up to 300-400mg/day if required | DEPRESSION PO Adult Initially 150mg/day in 3 divided doses, may increase by 50mg/day q3-7 days max 600mg/day. ER tablet: Initially 150mg/day HS, may increase by 75mg/day q3days max 375mg/day. Reduce dose once adequate therapeutic response is achieved |
| Contra: Hypersensitivity, post MI
Precautions: Major depression & other psychiatric disorders, history of CVD, patients with antihypertensives, seizure disorder, renal/hepatic impairment, elderly, priapism, abrupt withdrawal ADR: Serious: orthostatic hypotension, syncope, sedation, blurred vision, edema, HTN, tremor, arrhythmia, Others: myalgia, dyspnea, confusion, libido decreased, diarrhea, constipation, abdominal pain, headache, dizziness, fatigue, xerostomia, nausea DDI: Serious Macrolides cause sedation, Clonidine causes hypotension with bradycardia & sedation, Alcohol causes sedation, Warfarin efficacy is reduced, Thioridazine/Fluoxetine increases drug levels, Azoles Inhibits drug metabolism, Trifluoperazine/Chlorpromazine leads to hypotension, MAOIs leads to serotonin syndrome, Ritonavir markedly impairs drug clearance, Carbamazepine moderately decreases drug levels, Phenytoin toxicity is increased Diet: After food, ER tablet (before food) Monitor: Suicide ideation |