Article Contents ::
Details About Generic Salt :: Palonosetron
Main Medicine Class:: Gastrointestinal System Sub Medicine Class :: Anti Emetics
| 7D. ANTI-EMETICS in 7. GASTROINTESTINAL SYSTEM |
| PALONOSETRON |
| SECOND-GENERATION 5-HT3 RECEPTOR ANTAGONIST | ANTI-EMETIC |
| PK: D: Vd: 7-8 L/kg M: Liver E: Urine |
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Indications & Dose: CHEMOTHERPY ASSOCIATED NAUSEA & VOMITING IV Adult 0.25mg over 30sec administered 30min before start of chemotherapy | POSTOPERATIVE NAUSEA/VOMITING IV Adult 0.075mg over 10sec immediately before induction of anesthesiaUp to 1 day after surgery |
| Contra: Hypersensitivity
Precautions: DM, hepatic dysfunction, children, patients allergic to other 5-HT3 receptor antagonists, ventricular arrhythmia, patients with congenital long QT syndrome ADR: Serious: hypotension, tachycardia, bradycardia, QT prolangation, urinary retention, arrhythmia, metabolic acidosis, seizure, edema, Others: chills, hiccups, joint pain, arthralgia, constipation, hyperglycemia, diarrhea, fatigue, abdominal pain, headache, insomnia, dizziness, anxiety DDI: Serious Apomorphine causes hypotension Monitor: Vital signs, ECG, tachycardia, bradycardia, hypotension,electrolyte levels, CBC, urine glucose levels |