Article Contents ::
Details About Generic Salt :: Trimipramine
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 1D. ANTI-DEPRESSANTS in 1. NERVOUS SYSTEM |
| TRIMIPRAMINE |
| DIBENZAZEPINE TCA | ANTI-DEPRESSANT |
| PK: A: Rapid M: Hepatic E: Urine |
|
Indications & Dose: DEPRESSION PO Adult 50-75mg/day, gradually increased to 150-300mg/day Elderly Initially 50mg/day, increased gradually to 100mg/day |
| Contra: Hypersensitivity, heart block, cardiac arrhythmias, MI, severe liver disease
Precautions: Angle-closure glaucoma, pheochromocytoma, CVD, hepatic impairment, children, elderly, history of epilepsy ADR: Serious: tinnitus, bone-marrow depression, blood disorders, hypersensitivity reactions, orthostatic hypotension, tachycardia, angioedema, increased IOP, tremor, seizures, peripheral neuropathy, Others: dry mouth, constipation, urinary retention, blurred vision, drowsiness, urticaria, hyperthermia, headache, confusion, hallucinations, sour/metallic taste, stomatitis, nausea, vomiting, gastric irritation DDI: Serious MAOIs causes serotonin syndrome, Fluvoxamine/Diltiazem/Quinidine/Verapamil increases drug level, SSRIs increases drug levels, Venlafaxine/Bupropion leads to seizures Diet: With/without food |