Article Contents ::
Details About Generic Salt :: Fenofibrate
Main Medicine Class:: Cardiovascular System Sub Medicine Class :: Fluid , Electrolyte Preparations
| 4F. ANTI-HYPERLIPIDEMICS in 4. CARDIOVASCULAR SYSTEM |
| FENOFIBRATE |
| FIBRIC ACID DERIVATIVE | ANTI-HYPERLIPIDEMIC |
| PK: A: Well absorbed D: Extensive M: Hepatic/renal E: Urine, feces |
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Indications & Dose: HYPERTRIGLYCERIDEMIA PO Adult Micronized capsule: 43-130mg/day, Tablet: 54-160mg/day. Adjust dose at intervals of 4-8 wk Elderly Micronized capsule: 43mg/day, Tablet: 54mg/day | MIXED DYSLIPIDEMIA PO Adult Micronized capsule: 130mg/day, Tablet: 160mg/day. Adjust dose at intervals of 4-8 wk Elderly Micronized capsule: 43mg/day, Tablet: 54mg/day | PRIMARY HYPERCHOLESTEROLEMIA PO Adult Micronized capsule: 130mg/day, Tablet: 160mg/day. Adjust dose at intervals of 4-8 wk Elderly Micronized capsule: 43mg/day, Tablet: 54mg/day |
| Contra: Hypersensitivity, hepatic dysfunction, severe renal dysfunction, pre-existing gallbladder disease, patients with risk factors for myopathy, nephrotic syndrome, severe renal impairment
Precautions: Pancreatitis, cholelithiasis, concurrent use of warfarin, mild-to-moderate renal impairment, elderly ADR: Serious: Arrhythmias, ventricular extrasystoles, MI, atrial fibrillation, thrombocytopenia, leukopenia, hypoglycemia, rectal hemorrhage, renal dysfunction, asthma, varicose veins, angina, HTN, hypotension, PVD, vasodilation, ECG abnormalities, conjunctivitis, abnormal vision, PUD, cholelithiasis, prostatic disorder, hyperuricemia, tachycardia, herpes infect, edema, hypersensitivity reactions, Others: weight loss/gain, phlebitis, myositis, dyspnea, rash, diaphoresis, RTI, nausea, vomiting, diarrhea, constipation, Drowsiness, dizziness, fatigue, headache, migraine, insomnia, depression, vertigo, anxiety, neuralgia DDI: Serious Gemfibrozil increases the risk of gallstone formation, Pravastatin level is increased, Ciclosporin reduces renal function Diet: With food Monitor: CBC, lipid profile, LFTs |