Article Contents ::
Details About Generic Salt :: Lactulose
Main Medicine Class:: Gastrointestinal System Sub Medicine Class :: Cathartics,Laxatives,Fecal Softeners
| 7C. CATHARTICS/LAXATIVES/FECAL SOFTENERS in 7. GASTROINTESTINAL SYSTEM |
| LACTULOSE |
| OSMOTIC LAXATIVE |
| PK: A: Poor M: Colonic flora E: Feces, urine |
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Indications & Dose: CONSTIPATION PO Adult Initially 10-20g/day in single dose or in 2 divided doses, may be adjust dose according to response Child 1 month–1 yr: 2.5mL BID, 1–5 yrs: 2.5–10mL BID, 5–18 yr: 5–20mL BID, adjust dose according to response | PORTAL SYSTEMIC ENCEPHALOPATHY PO Adult Prevention: 20-30g (30-45mL) TID/QID, adjust dose q1-2days to produce 2-3 soft stools/day. Treatment: 20-30g (30-45mL) q1h to induce rapid laxation, reduce to 20-30g (30-45mL) TID/QID after laxation Child Prevention: Infants: 1.7-6.7g/day (2.5-10mL/day) in divided doses, Children: 26.7-60g/day (40-90mL/day) in divided doses, adjust dose to produce 2-3 stools/day | RECTAL Adult Dilute 200g (300mL) with 700mL water or NS given via rectal balloon catheter for 30-60min, may be repeat q4-6h if needed |
| Contra: Patients requiring low-galactose diet, galactosemia, intestinal obstruction
Precautions: DM, elderly, children, lactose intolerance ADR: Serious: hypokalemia, Others: hypernatremia, nausea, vomiting, diarrhea, intestinal cramps, abdominal distention, flatulence, hyperglycemia DDI: Serious Coumarins increases the risk of over-anticoagulation (long-term use) Diet: With/without food Monitor: BP (standing/supine), serum electrolytes, serum ammonia, bowel movement patterns, fluid status |