Details About Generic Salt ::  Papaveri

Main Medicine Class:: Peripheral vasodilator   

(pap-PAV-uhr-een HIGH-droe-KLOR-ide)

Pavabid Plateau Caps, Pavagen TD

Class: Peripheral vasodilator

Drugs Class ::

 Action Directly relaxes tone of all smooth muscle, especially when spasmodically contracted. Causes vasodilatation of blood vessels of the coronary, cerebral, pulmonary and peripheral arteries; relaxes musculature of bronchi, GI tract, ureters and biliary system.

Indications for Drugs ::

 Indications

Oral form: Relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. Parenteral form: Vascular spasm associated with acute MI (coronary occlusion), angina pectoris, peripheral and pulmonary embolism, peripheral vascular disease in which there is a vasospastic element, certain cerebral angiospastic states, visceral spasm (eg, ureteral, biliary, and GI colic). Unlabeled use(s): Intracavernous injection for impotence.

Drug Dose ::

 Route/Dosage

Ischemia

ADULTS: PO 100 to 300 mg 3 to 5 times daily (immediate-release tablets) or 150 mg q 8 to 12 hr or 300 mg q 12 hr (sustained-release capsules).

Vascular Occlusion

ADULTS: IV/IM Initial dose: 30 mg. Repeat doses: 30 to 120 mg q 3 hr prn.

Impotence

ADULTS: IV 2.5 to 60 mg as intracavernous injection (usually combined with phentolamine mesylate).

Contraindication ::

 Contraindications Complete atrioventricular (AV) heart block; intracorporeal injection for impotence.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Unknown. Children: Safety and efficacy not established. Glaucoma: Use drug with caution. Hepatic hypersensitivity: Has been reported.

Drug Side Effects ::

 Adverse Reactions

CV: Increase in heart rate; slight increase in BP. CNS: Depression; dizziness; vertigo; headache; drowsiness; sedation; lassitude; malaise; lethargy. DERM: Flushing of face; sweating; pruritus. GI: Constipation; nausea; diarrhea; abdominal distress; dry mouth; anorexia. HEPA: Jaundice; hepatitis. HEMA: Eosinophilia. RESP: Increased depth of respiration.

Drug Mode of Action ::  

 Action Directly relaxes tone of all smooth muscle, especially when spasmodically contracted. Causes vasodilatation of blood vessels of the coronary, cerebral, pulmonary and peripheral arteries; relaxes musculature of bronchi, GI tract, ureters and biliary system.

Drug Interactions ::

 Interactions

CNS depressants: Effects may be additive. Levodopa: May reduce effectiveness of levodopa. INCOMPATIBILITIES: Lactated Ringer’s solution incompatible with parenteral formulation; do not mix.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Assess mental status before and during therapy (eg, lassitude, sedation, malaise, headache, depression).
• Assess bowel status and bowel sounds before administering drug and periodically during treatment.
• Monitor patient’s BP, both lying and standing.
• Monitor liver function tests.
• Monitor ECG. If cardiac changes occur on ECG, notify physician immediately.
• If AV block, flushing, headache, jaundice, abdominal distress, constipation, or diarrhea develop, notify physician.

Drug Storage/Management ::

 Administration/Storage

• Give at evenly spaced intervals throughout day.
• Do not crush or allow patient to chew sustained-release capsules.
• Do not administer in Lactated Ringer’s solution because precipitate will develop.
• Administer parenteral form slowly over 1 to 2 min to minimize adverse effects.
• Store at room temperature.

Drug Notes ::

 Patient/Family Education

• Instruct patient to take medication at evenly-spaced intervals throughout day.
• Advise patient with glaucoma to undergo regular eye examinations.
• Instruct patient to report the following symptoms to physician: Flushing, sweating, headache, tiredness, jaundice, skin rash, nausea, anorexia, abdominal distress, constipation, or diarrhea.
• Advise patient to avoid smoking and intake of alcoholic beverages or other CNS depressants.
• Caution patient to avoid sudden position changes to prevent orthostatic hypotension.
• Advise patient that drug may cause dizziness, vertigo, and drowsiness, and to use caution while driving or performing other tasks requiring mental alertness.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.