The Brand Name CUROMID Has Generic Salt :: ROCURONIUM 

CUROMID  Is From Company ZENOTECH LAB. Priced :: Rs. 275.00/475.00

CUROMID have ROCURONIUM is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Endotracheal intubation, Aid controlled ventilation, Muscle relaxant in general anesthesia

Drug Dose ::

Intravenous Muscle relaxant in general anaesthesia, Endotracheal intubation, Aid controlled ventilation Adult: Initially, 600 mcg/kg by inj. Higher doses of 1 mg/kg may be used for intubation during rapid sequence induction of anaesthesia. Maintenance: 150 mcg/kg by inj (may reduce to 75-100 mcg/kg if inhalational anaesthesia is used) or by infusion at a rate of 300-600 mcg/kg/hr. Doses should be based on lean body weight for obese patients weighing >30% above the ideal body weight. Child: Infants and children >1 mth: Initially, 600 mcg/kg by inj. Maintenance: 150 mcg/kg by inj or by infusion at a rate of 300-600 mcg/kg/hr, maintenance doses may be required more frequently than in adult patients. Elderly: Reduced maintenance doses: 75-100 mcg/kg. Hepatic impairment: or biliary tract disease: Initially, 600 mcg/kg by inj. Maintenance: 75-100 mcg/kg.

Contraindication ::

Hypersensitivity.

Drug Precautions ::

Pulmonary disease, hepatic, renal impairment, biliary disease, electrolyte/acid-base abnormalities, neuromuscular diseases, DM, dehydrated or severely-ill patients, patients with >40% burns. Ventilation must be supported during neuromuscular blockade. Pregnancy and lactation. Doses >900 mcg/kg may have vagolytic activity.

Drug Side Effects ::

Itching and erythematous reactions at the inj site and/or generalised histaminoid reactions. CV changes. Tachycardia and increase in BP. Potentially Fatal: Abnormal ECG, arrhythmia, bronchospasm, anaphylaxis and malignant hyperthermia.

Pregnancy category ::

3

Drug Mode of Action ::  

Rocuronium is a competitive neuromuscular blocker that acts by blocking the binding of acetylcholine to receptors on the motor endplate, inhibiting depolarisation.

Drug Interactions ::

May cause enhanced block when used with lidocaine, procainamide, quinidine, verapamil, aminoglycosides, inhalational anaesthetics and vancomycin. May cause prolonged paralysis when used with clindamycin. Anticholinesterases such as pyridostigmine and galantamine may antagonise the effect of rocuronium. Chronic use of carbamazepine or phenytoin may lead to resistance to rocuronium.