The Brand Name FAMCIMAC Has Generic Salt :: FAMCICLOVIR 

FAMCIMAC  Is From Company Macleods Priced :: Rs. 79

FAMCIMAC have FAMCICLOVIR is comes under Sub class Anti Virals (Non Retroviral) of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Anti Virals (Non Retroviral) 

Indications for Drugs ::

Genital herpes, Herpes zoster, Herpes labialis, CMV infections, Mucocutaneous herpes

Drug Dose ::

Adult: PO Herpes zoster 250 mg 3 times/day for 7 days. Renal impairment: For immunocompromised patients: CrCl >40 ml/min: 500 mg tid; 30-39 ml/min: 250 mg tid; 10-29 ml/min: 125 mg tid. CrCl (ml/min) 30-59 For immunocompetent patients: 250 mg bid. 10-29 For immunocompetent patients: 250 mg once daily. Recurrent episodes of genital herpes 125 mg twice daily for 5 days. Renal impairment: CrCl (ml/min) 10-29 For immunocompetent patients: 125 mg once daily. Suppression of recurrent episodes of genital herpes 250 mg twice daily. Recurrent mucocutaneous herpes in HIV-infected patients 500 mg twice daily for 7 days. Renal impairment: CrCl (ml/min) >30 For immunocompetent patients: 250 mg bid. 10-29 For immunocompetent patients: 125 mg bid Genital herpes For 1st episodes: 250 mg 3 times/day for 5 days. Renal impairment: CrCl (ml/min) 30-59 For immunocompetent patients: 250 mg bid. 10-29 For immunocompetent patients: 250 mg once daily. Recurrent herpes labialis 1.5 g as a single dose at the 1st sign or symptom.

Contraindication ::

Hypersensitivity. Lactation.

Drug Precautions ::

Renal impairment. Pregnancy.

Drug Side Effects ::

Dizziness, headache, diarrhoea, constipation, nausea, vomiting, hallucinations, confusion, pruritus, abdominal pain, fever.

Pregnancy category ::

2

Drug Mode of Action ::  

Famciclovir rapidly undergoes biotransformation to penciclovir, which has inhibitory activity against HSV types 1 (HSV-1) and 2 (HSV-2) varicella-zoster virus (VZV). Thymidine kinase then phosphorylates penciclovir to a monophosphate form, which is then converted to penciclovir triphosphate. This inhibits HSV-2 DNA polymerase by competing with deoxyguanosine triphosphate, thus inhibiting herpes viral DNA synthesis and replication.

Drug Interactions ::

Reduced renal excretion resulting to increased plasma concentration w/ probenecid. Raloxifen may reduce the formation of penciclovir, the active metabolite of famciclovir.